Antimicrobial Resistance Distribution and Quorum-Sensing Regulation of Enterococcal Strains, Isolated from Hospitalized Patients

Background: Enterococci are intrinsically resistant/tolerant to various antimicrobial agents and can also acquire combine different mechanisms of resistance, including quorum-sensing regulation, most active compounds, which makes enterococcal infection treatment even more challenging. The aim this study was evaluate the pattern resistance analyze frequency asa1 esp genes in clinical isolates representing genus Enterococcus. Methods: Multiplex PCR assays were performed for identification 110 determination their antibiotic susceptibility presence asa1/esp genes. Additionally, tested by Kirby–Bauer disk diffusion method. Results: 90% identified as Enterococcus faecalis 10% faecium. Quorum-sensing regulation present 109 isolates. Aminoglycoside (aac(6′)/aph(2″)-, quinolone (emeA)-, β-lactams (TEM)-, vancomycin (vanA)-resistance detected 108 All vanB negative. According method, 39% expressed multidrug (MDR) 33% MDR E. faecium vancomycin-resistant. Conclusion: large percentage enterococci possessing indicated a possible connection between drug resistance. Therefore, regular monitoring spp., virulence factors needed. It is important prevent host colonization through elimination leading expression